Astérix et Obélix partent pour Lutèce acheter une nouvelle serpe au druide Panoramix. Mais sur place, ils se rendent compte que la contrebande de serpes fait rage... à partir de 6 ans.
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.
Explaining U.S. Imprisonment builds on and extends some of the contemporary issues of women in prison, minorities, and the historical path to modern prisons as well as the social influences on prison reform.
Author: Hans G. Börner, Jean-Francois Lutz
Publisher: Springer Science & Business Media
Erik Wischerhoff, Nezha Badi, André Laschewsky and Jean-François Lutz Smart Polymer Surfaces: Concepts and Applications in Biosciences; S. Petersen, M. Gattermayer and M. Biesalski Hold on at the Right Spot: Bioactive Surfaces for the Design of Live-Cell Micropatterns; Julien Polleux Interfacing Cell Surface Receptors to Hybrid Nanopatterned Surfaces: A Molecular Approach for Dissecting the Adhesion Machinery; Abigail Pulsipher and Muhammad N. Yousaf Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology; D. Volodkin, A. Skirtach and H. Möhwald LbL Films as Reservoirs for Bioactive Molecules; R. Gentsch and H. G. Börner Designing Three-Dimensional Materials at the Interface to Biology; Joerg C. Tiller Antimicrobial Surfaces;
Single Crystal Diffractometry
Author: U. W. Arndt, B. T. M. Willis
Publisher: Cambridge University Press
Originally published in 1966, this book covers all aspects of single crystal diffractometry.
Field Responsive Polymers
Author: Ishrat M. Khan, Joycelyn S. Harrison
Publisher: Amer Chemical Society
Field responsive polymers, or smart polymers, will play a key role in the emergence of a wide array of new devices such as those manufactured by the aerospace, communications, and biomedical industries. The twenty-two chapters in this volume present state-of-the-art research and discuss some of the potential applications of electroresponsive, photoresponsive, and responsive polymers in chemistry and biology. Topics discussed include: microwave active responsive polymers; the design of solid polymer electrolytes for electrochromic devices; thin films for electro-optic modular applications, photorefractive and NLO polymers; thermoreversible polymers and the application of responsive polymers in peptide drug delivery systems. This comprehensive resource is perfect for polymer scientists, materials scientists, and physicists.
"The untimely passing of Professor Toyoichi Tanaka, internationally regarded as the father of modern research on polymer gels, prompted the gathering of gel researchers at the 7th Pacific Polymer Conference, held in Oaxaca, Mexico, December 5-7, 2001. This issue features a range of topics related to gels presented at the Microsymposium in honor of the Late Professor Toyoichi Tanaka."--BOOK JACKET.
The Metamorphoses of Tintin, a pioneering book first published in French in 1984, offers a complete analysis of Hergé's legendary hero.
Is every man killed in combat reborn in the sky in the form of a star? Is seeing a bus in your dreams really a sign of impending death? In 1917, Jan Van Meer, an operative with the Allies' intelligence services and a renowned expert on folklore, travels across Europe in search of an engineer named Hellequin, inventor of the dream cannon and barbed plant-wire now obsessed with reading the ruins of war. Van Meer's mission: not to find Hellequin at all costs. With his trademark wit, original drawing style, and wild animation, David B. takes viewers deep into the torment of the Great War, where beliefs and superstitions inextricably mix with the horror of reality.
Praise for Incidents in the Night, finalist for the Los Angeles Times Book Prize (Graphic Novel category): "One of 10 Best Comics and Graphic Novels of the year."--Time "A treat for sophisticated adult story omnivores with a taste for bizarre mysteries."--Library Journal "Incidents owes more than a bit to Jorge Luis Borges's short stories."--Douglas Wolk, The Washington Post At the end of first Incidents in the Night, David B. met an uncertain demise in a bizarre cliffhanger. In Book 2, the worlds of Epileptic and Incidents in the Night become entangled as the author's dead brother, Jean-Christophe, joins the cast to solve the mystery and uncover the occult machinations of the mad editor, Émile Travers. Book 2 is another treat for lovers of books and literary mysteries. Once again the translation is by acclaimed novelist Brian Evenson. David B. is one of the world's finest cartoonists and a co-founder of the legendary L'Association collective. He is the author of many graphic novels including Epileptic, which was awarded Angouleme International Comics Festival Prize for Scenario and the Ignatz Award for Outstanding Artist. Brian Evenson is the author of eleven prize-winning books of fiction, including The Open Curtain, Last Days, Windeye, and Immobility. His work has been translated into over a dozen languages. He lives and works in Providence, Rhode Island, where he teaches at Brown University.
Seventeenth-century Japan is a land in upheaval. A land of wandering Ronins and beautiful Geisha. Into this strange and violent world come five of Marvel's greatest heroes as you've never seen them before: Pyslocke, Punisher, Deadpool--and Hulk.
Author: Jean-Pierre Dionnet, Jean-Claude Gal
Grumpy Old Christmas
Author: Stuart Prebble
Publisher: Hachette UK
The highly successful 'Grumpies' return full of the Christmas spirit. So - 'tis the season to be jolly is it? Well, not in the household of the Grumpy Old Man it isn't. In the case of the GOM, 'tis the season to have to put up with even deeper layers of vexation than usual, and the only thing worth celebrating is that it looks as though you might after all be surviving to the end of what has been another crap year. Everything about Christmas gets up our snitches. Everything. From the breakfast telly presenters who tell us it's now just 120 shopping days to go, to the annual festive strike by airport baggage handlers. From office parties where drunken juniors have waited the whole year to tell you what 'the trouble with you is...', to parents videoing their precocious brats at the atrocious school nativity play where your kid is playing the part of the donkey's rear end. From the woman next door who drops in to show your wife the diamond ring her prat of a husband has bought her, to the 150th opportunity to see 'Whistle Down the Wind' on the telly. And speaking of wind, there's the festive Xmas turkey that tastes like blotting paper soaked in a puddle and sends your digestive system to hell. And how on earth are we really supposed to look happy when someone buys us a tie with a picture of xxxxing Santa on it? Eh?
This Desirable Plot
Author: Norman Thelwell
Publisher: Random House (UK)
This collection of Thelwell cartoons focuses on the property market and its pitfalls. It looks at estate agents' jargon, the techniques of buying and selling, the hazards of owning a country cottage and the lunacy of converting old buildings.