Author: David Anz
Publisher: Schattauer Verlag
Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.
Author: Hans-Peter Deigner, Matthias Kohl
Publisher: Academic Press
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation Encompasses easy access to relevant approaches, interactions and original literature
Author: Isabel Klusman, Effy Vayena
Publisher: vdf Hochschulverlag AG
Die medizinische Forschung und die Gesundheitsversorgung stehen vor einem grundlegenden Wandel. Dank der Entschlüsselung des menschlichen Genoms in 2001 ist es nun möglich, Erbanlagen mit Anfälligkeit für Krankheiten oder Reaktionen auf Medikamente zu korrelieren. Mit diesen bisher kaum erforschten Möglichkeiten wird die personalisierte Medizin einen grossen Schritt näher rücken. Einerseits wird die Gesundheitsversorgung und die medizinische Forschung grundlegend beeinflusst, etwa durch eine frühere Erkennung und Vorbeugung von Krankheitsrisiken. Anderseits stellt die persönliche Information des Erbguts auch neue Fragen an die Gesellschaft und das Individuum. Die Beiträge beleuchten die Möglichkeiten und Herausforderungen der personalisierten Medizin.
Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.
Easy-to-read and fast support at the point of care - EBM Guidelines: Summarises the best available evidence - Cochrane reviews - DARE abstracts - Clinical Evidence topics - original articles in medical journals - abstracts in the Health Technology Assessment Database - NHS Economic Evaluation Evaluates and grades the strength of all.
Comprehensive Biomedical Physics is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color
The 1918-19 influenza epidemic killed more than fifty million people worldwide. The SARS epidemic of 2002-3, by comparison, killed fewer than a thousand. The success in containing the spread of SARS was due largely to the rapid global response of public health authorities, which was aided by insights resulting from mathematical models. Models enabled authorities to better understand how the disease spread and to assess the relative effectiveness of different control strategies. In this book, Lisa Sattenspiel and Alun Lloyd provide a comprehensive introduction to mathematical models in epidemiology and show how they can be used to predict and control the geographic spread of major infectious diseases. Key concepts in infectious disease modeling are explained, readers are guided from simple mathematical models to more complex ones, and the strengths and weaknesses of these models are explored. The book highlights the breadth of techniques available to modelers today, such as population-based and individual-based models, and covers specific applications as well. Sattenspiel and Lloyd examine the powerful mathematical models that health authorities have developed to understand the spatial distribution and geographic spread of influenza, measles, foot-and-mouth disease, and SARS. Analytic methods geographers use to study human infectious diseases and the dynamics of epidemics are also discussed. A must-read for students, researchers, and practitioners, no other book provides such an accessible introduction to this exciting and fast-evolving field.
PET-CT Hybrid Imaging
Author: Otmar Schober, Walter Heindel
Written by a multidisciplinary team of experts in radiology and nuclear medicine, this lavishly illustrated handbook presents an evidence-based look at the most up-to-date image-fusion technology in clinical use today. The authors combine multislice spiral CT anatomic images with specific sensitive molecular images of PET in one examination to give readers a full understanding of this evolving technology.The book places special emphasis on tumor imaging, with additional chapters on the imaging of inflammatory, cardiovascular, and neurodegenerative diseases. Leading clinicians provide systematic discussion of patient preparation, recommendations for imaging protocols for specific indications, and examination techniques such as slice orientation and positioning. To prepare the reader for daily practice, CT and PET-CT scans appear throughout the text side-by-side with explanations of their interpretation.Highlights: 616 high-quality images - including 175 in full color - complement the text Easy-to-reference textboxes and sidebars present key concepts, pearls, and pitfalls Detailed summaries at the end of each chapter facilitate rapid review Carefully selected suggestions for further reading at the end of each section A comprehensive glossary of frequently used terms and a list of common abbreviations Ideal for practicing radiologists, radiologic technologists, and radiology residents, PET-CT Hybrid Imaging is an essential reference for anyone who needs to quickly compare and interpret PET-CT images. It is also an excellent preparation tool for Board examinations.
Infections in Hematology
Author: Georg Maschmeyer, Kenneth V.I. Rolston
Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.
The Alzheimer Conundrum
Author: Margaret Lock
Publisher: Princeton University Press
Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.
Cancer and Nutrition
Author: Roslyn B. Alfin-Slater, David Kritchevsky
Publisher: Springer Science & Business Media
The role of nutrition in neoplasia has been of longstanding concern. The subject was addressed by investigators in the first decade of this century, but was dropped. Vigorous attention was paid to this area of oncology in the 1940s, primarily due to the efforts of Dr. A. Tannenbaum at the Michael Reese Hospital in Chicago and the group at the University of Wisconsin in Madison. However, interest waned again until the 1970s when the question of diet and cancer was addressed and it has since been at the forefront of cancer research. The present volume (7) of Human Nutrition: A Comprehensive Treatise summarizes current knowledge in the area of nutrition and cancer. The first chapter is an overview written by John Higginson, whose contribution to understanding of cancer and nutrition spans several decades. The next essays cover epidemiology and physiology. The ensuing chapters address, in tum, those dietary factors relating to nutrition and cancer, namely, carbohydrates, protein, fat, cholesterol, calories, lipotropics, fiber, fruits and vegetables, vitamins, and alcohol. In a field moving as rapidly as this one is now, we can expect to miss a few late-breaking developments, but generally, the literature has been well covered through some time in 1988. Work relating to the effects of diet on oncogenes is in its very early development and has not been addressed as an entity per se.
Author: Konrad Maurer, Ulrike Maurer
Publisher: Columbia University Press
Although Alzheimer's disease has been well documented throughout the twentieth century, no biography has been written of the man who was its namesake. This biography is the first, and it covers the life of Alois Alzheimer (1864-1915), his discovery of the disease that currently afflicts some thirty to forty million people, and his subsequent research.