Drug Like Properties

Author: Li Di
Publisher: Academic Press
ISBN: 0128013222
Size: 25.12 MB
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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable ...

Using Mass Spectrometry For Drug Metabolism Studies Second Edition

Author: Walter A. Korfmacher
Publisher: CRC Press
ISBN: 9781420092219
Size: 78.24 MB
Format: PDF, Docs
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... metabolites: Kinetic differences between generated and preformed metabolites
, Toxicol. Appl. Pharm., 217, 143, 2006. US Food and Drag Administration
Guidance for Industry Safety Testing of Drag Metabolites, 2008, available at: http
://www.fda.gov/downloads/Drugs/GuidanceCompliance Regulatoryinformation/
Guidances/ucm079266.pdf Kerns, E.H. and Di, L., Drug-Like Properties:
Concepts, Structure Design and Methods: From ADME to Toxicity Optimization,
Elsevier/Academic ...

Developing Solid Oral Dosage Forms

Author: Yihong Qiu
Publisher: Academic Press
ISBN: 0128026375
Size: 40.87 MB
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... and pharmacokinetics, the development of formulations for drug discovery
support, emerging manufacturing technologies, and much more • Incorporates
new case studies throughout the book • Contains a section completely devoted to
regulatory aspects, including global product regulation and international
perspectives Related Titles • Di and Kerns, Drug-Like Properties: Concepts,
Structure Design and Methods from ADME to Toxicity Optimization, Second
Edition, January 2016, ...

Admet For Medicinal Chemists

Author: Katya Tsaioun
Publisher: John Wiley & Sons
ISBN: 9780470922811
Size: 72.49 MB
Format: PDF, Kindle
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Introduction to Mass Spectrometry: Instrumentation, Applications, and Strategies
for Data Interpretation, 4th Edition, Wiley, Hoboken, NJ, 2007, p. 862.
Ramanathan, R. (ed.). ... Mass Spectrometry Desk Reference, 2nd Edition, Global
View Publishing, Pittsburgh, PA, 2006, p. 198. Vekey, K., Telekes, A., and Vertes,
... Drug-like Properties: Concepts, Structure Design and Methods: From ADME to
Toxicity Optimization, Academic Press, New York, 2008, p. 552. van de
Waterbeemd, H. and ...

Hayes Principles And Methods Of Toxicology Sixth Edition

Author: A. Wallace Hayes
Publisher: CRC Press
ISBN: 1842145363
Size: 36.23 MB
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Kerns, E. H. and Di, L. (2008): Toxicity methods. In: Druglike Properties: Concepts
, Structure Design and Methods from ADME to Toxicity Optimization. Academic
Press, New York, pp. 386–398. Kier, L. D. (1985): Use of the Ames test in
toxicology. Reg. Toxicol. Pharmacol., 5:59–64. Klaassen, C. D. and Doull, J. (
1980): Evaluation of safety: Toxicologic evaluation. In: Toxicology: The Basic
Science of Poisons, 2nd edn., eds. J. Doull, C. D. Klaassen, and M. O. Amdur.
Macmillan, New ...

Biochemical Pharmacology

Author: Michael Palmer
Publisher: John Wiley & Sons
ISBN: 1118230337
Size: 59.79 MB
Format: PDF, Docs
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E. Kerns and L. Di, Drug-like properties: concepts, structure design and methods:
from ADME to toxicity optimization, Academic Press, 2008. F. Kratz et al., “
Prodrug strategies in anticancer chemotherapy." ChemMedChem 3 (2008), 20-
53. D. D. Lasic and D. Papahadjopoulos, “Liposomes revisited," Science 267 (
1995), 1275-1276. D. Law et al., “Physicochemical considerations in the
preparation of amorphous ritonavirpoly(ethylene glycol) 8000 solid dispersions,"
J. Pharm. Sci.

The Organic Chemistry Of Drug Design And Drug Action

Author: Richard B. Silverman
Publisher: Academic Press
ISBN: 0123820316
Size: 80.48 MB
Format: PDF
View: 345
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Mechanistic and synthetic organic chemistry play a central role in numerous
critical aspects of the drug discovery process, most prominently in generating
sufficient numbers of compounds for lead discovery, in effectively optimizing
compounds for potency, selectivity, and intellectual property position, and in
understanding factors governing ADME. The ensuing chapters will delve in detail
into the organic chemistry of these critical aspects of drug design and drug action.